背景
Dexmedetomidineproducessedationwhilemaintainingadegreeofarousabilityandmayreducethedurationofmechanicalventilationanddeliriumamongpatientsintheintensivecareunit(ICU).Theuseofdexmedetomidineasthesoleorprimarysedativeagentinpatientsundergoingmechanicalventilationhasnotbeenextensivelystudied.
右美托咪定可在保持一定程度的唤醒性的同时产生镇静作用，并且可以减少重症监护病房（ICU）患者的机械通气和谵妄的持续时间。在接受机械通气的患者中使用右美托咪定作为唯一或主要的镇静剂尚未得到广泛研究。
方法
Inanopen-label,randomizedtrial,weenrolledcriticallyilladultswhohadbeenundergoingventilationforlessthan12hoursintheICUandwereexpectedtocontinuetoreceiveventilatorysupportforlongerthanthenextcalendardaytoreceivedexmedetomidineasthesoleorprimarysedativeortoreceiveusualcare(propofol,midazolam,orothersedatives).Thetargetrangeofsedation-scoresontheRichmondAgitationandSedationScale(whichisscoredfrom?5[unresponsive]to+4[